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When the synergistic excitatory-inhibitory balance (EIB) of glutamate and GABA is optimal, the brain is metabolically, functionally, and operationally efficient and effective at learning new information, recalling memories, processing sensory information, controlling motor movements, expressing emotions, facilitating neuroplasticity, and maintaining network stability

There is also a subset of users who experience delayed onset, with skin sensitivity appearing after 8 to 12 weeks of stable dosing

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