In contrast to inhibiting H 2 S biosynthesis, some studies have addressed the advantage of poisoning cancer cells with high levels of H 2 S, by using donors that release H 2 S in the tumour and somehow block the most important signalling pathways sustaining cancer survival, such as PI3K and MAPK
If using both: Many patients apply the tretinoin/niacinamide product at night and GHK-Cu in the morning, or alternate evenings
The initial purity of the GHK-Cu peptide is foundational to its stability
In two randomised controlled trials (RCT) in patients with coexisting ID anaemia and sub-clinical hypothyroidism, treatment with iron and L-T4 together was considerably more effective in improving iron status than was treatment with iron alone ( Reference Ravanbod, Asadipooya and Kalantarhormozi 60 , Reference Cinemre, Bilir and Gokosmanoglu 61 )
however, emerging reports suggest that, in rare cases, they may trigger autoimmune responses, including GD
