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[1] By age 40, many men are 20-30% below their peak levels

They are documented patterns in self-reported community sources, included to show how users have described handling adverse effects in the complete absence of trial-defined safety data

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For example, specific trials with semaglutide have reported lean mass losses anywhere from 0% to 40% of total weight lost, though fat loss generally outweighs muscle loss, resulting in a higher proportion of lean mass relative to overall body weight