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A systematic review and meta-analysis published in PMC found that cagrilintide actually had the lowest odds ratio for nausea, vomiting, and diarrhea compared to other incretin-based therapies

And, if polymorphisms in the glucoronosyI transferases reduce the V max values to 10% of normal then the number of hepatocytes drops to about 10% of normal after 20 hours

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Use should be discontinued upon observance of any untoward reaction