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Although the precise mechanism of IGFBP-2 oncogenesis in bladder cancer (or other cancers) is unclear, it has a defined role in stimulating angiogenesis and metastasis through IGF1R as described above [40], and its reported oncogenic signaling through integrin- 1 and ERK activation [46] is consistent with the known interaction between activated IGF1R and integrin- 1 with scaffolding by RACK1 and FAK, which promotes proliferative ERK signaling as well as EMT and increased invasiveness [47] (Fig

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Other potential causes should be ruled out in patients with neuropathy symptoms