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This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine
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Cannon RD, Lamping E, Holmes AR, Niimi K, Baret PV, et al
Acta 1797 , 878889 (2010)
A common guideline used in various studies and clinical observations is 20 mg to 40 mg of glutathione per kilogram of body weight
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