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In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

& Macaulay, V

10.1016/j.smrv.2016.06.009 95 RiquelmeE.ZhangY.ZhangL.MontielM.ZoltanM.DongW.et al (2019)

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The most significant cytotoxic effectsthat is, those leading to the highest levels of eryptosiswere observed at high concentrations and long exposure times (24 h), indicating a time- and dose-dependent relationship (time- and dose-dependent effects)