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Activation of tubular epithelial cells in diabetic nephropathy

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

Bittner B, Richter W, Schmidt J

Early homocysteine research attempting to identify the relationship between homocysteine and health noted that incremental increases in homocysteine levels were accompanied by a higher risk of cardiovascular disease and death

These observations were further confirmed by Hoechst 33342 staining, which revealed extensive detachment of cells from the cell culture substratum and increases in apoptotic bodies of HepG2 cells incubated with H 2 O 2 and TNF for 16 h (Fig