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This participant was already taking tirzepatide when she enrolled in the trial, but before any stimulation was delivered, giving us a unique opportunity to make foundational observations about how the drug alters brain signals. At first, results were promising: As patient 3s tirzepatide levels reached full dosage, craving-linked NAc activity in her brain went dormant and she had no obsessive thoughts about food

During pregnancy, night-time concentrations of melatonin increase steadily after 24 weeks of gestation

While specific data on micronutrient status during tirzepatide therapy are limited, clinical experience suggests that maintaining optimal nutritional status supports the preservation of lean muscle mass during weight loss, enhances energy levels, and promotes overall treatment tolerability and success

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