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Patients who experienced hair loss on semaglutide and switch to tirzepatide, or who explore newer options like retatrutide or cagrilintide , should implement the prevention protocols from day one of the new medication
RCD plays a central role in DKD, overactivated TECs apoptosis causes tubular injury, autophagy deficiency disrupts cellular energy recycling and homeostasis, ferroptosis exacerbates mitochondrial injury via lipid peroxidation and iron overloading, and pyroptosis causes overactivated local cascadic inflammatory response to aggravates renal damage (13, 132, 224)
It can feel awkward or even embarrassing to talk about these changes, but they are real and linked to the biology of rapid weight loss
When in doubt, gently nudge yourself back to the basics and see how that works for you