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Cross-trial comparisons with dual-agonist agents such as tirzepatide are exploratory only no head-to-head trials have been conducted and should be interpreted with caution
Previously, we demonstrated that CAV-1 reduction increased STAT3 phosphorylation in human keratinocytes and that CSD reduced the number of pSTAT3-positive cells in the epidermis of mice with IMQ-induced psoriasis-like inflammation 6
In our current study, inhibiting PFKFB3 with 3PO not only repressed glycolytic lactate production but also potently inhibited the activation of NLRP3 inflammasome in TGF-1 + IL-1-activated lung fibroblasts
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