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PD-L1 is upregulated on osteosarcoma cells and interacts with PD-1 on activated T cells to induce exhaustion and apoptosis (37, 38)

Further, because the only large-scale trials of GLP-1 agonists have been conducted in obese or overweight study populations, we dont yet know if these drugs affect body composition in normal-weight individuals in an equivalent manner

You are unlikely to see any positive impact if you use the medicine for less than three months, and we often recommend patients stay on them for 12-24 months to increase the likelihood of sustained weight loss. Taking the medicine for the long-term helps cement healthier habits eating less, exercising more that increase the odds for permanent improvement after getting off the medicine

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