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The rationale for senolytics is that clearing these cells removes their chronic SASP burden, allowing tissue homeostasis to be partially restored
In contrast, in the Cagri-AMY 1 R-Gs structure, L119 RAMP1 is likely to clash with a rearranged imidazole side chain of H296 ECL2 that is observed when Cagri is bound to CTR and likely accounts for the different orientation of the linker in the Cagri bound AMY 1 R (Fig
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(1) Sikiric, Predrag et al
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