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Next, Cys63 nucleophilically attacks the sulfide of Cys58, releasing a GS-anion, which, in turn, picks up a solvent proton and is released from the enzyme, thereby creating the second GSH
The neurons of the cortical cerebral, cerebellar region, hippocampus, and hypothalamus were counted in 10 different high-powered fields (HPF, 400x) and 3 to 5 serial sections of each sample were used to do the count as described in The field size was 0.24 m 2
The VDss is the theoretical volume that a drug needs to be uniformly distributed to produce the same plasma concentration
10.1016/j.celrep.2020.107538 Cell Rep
Dichloroacetate and cancer: new home for an orphan drug
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