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Mahadevappa R, Ma R, Kwok HF

HDAC6 inhibitors such as tubastatin A and the clinically approved ACY-1215 (rocilinostat) enhance aggresome formation and autophagic clearance, reducing tau and -synuclein aggregates in AD and PD models

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Additionally, GLP-1 receptor agonists have demonstrated dual benefits in reducing headache symptoms and promoting weight loss in patients with idiopathic intracranial hypertension, offering therapeutic advantages for conditions involving both metabolic dysregulation and chronic pain 63