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Normally, when you eat, GLP-1 is released naturally and has the following actions: Signals the stomach to release food slowly Stimulates the pancreas to stop releasing glucagon, and start releasing insulin to prepare for a spike in blood sugar (Eventually) travels to the brain and acts on several areas involved in appetite regulation, shutting down the desire for food These are powerful effects, but they are tempered by the fact that GLP-1 doesnt stick around for very long

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As noted previously, currently we do not have any large clinical trials for the treatment of HF or CKD in patients with or without T2D using GLP-1RA

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