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Keep the medication in its original vial and box until use, to protect it from light

Target selectivity of vertebrate notch proteins

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Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion

The authors employed rigorous in vitro and in vivo experiments to validate the efficacy of this compound, revealing its ability to activate the receptor and stimulate insulin secretion in a glucose-dependent manner