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For pain management following TBI, the anti-inflammatory effects of these peptides provide secondary benefits beyond direct neuroprotection
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A randomized controlled trial of chronic pain from osteoarthritis in adults found similar benefit from acetaminophen and ibuprofen.[23] However, a randomized controlled trial of acute musculoskeletal pain in children found that the standard OTC dose of ibuprofen (400 mg) gives greater relief of pain than the standard dose of paracetamol (1000 mg).[24] In recommended doses, paracetamol does not irritate the lining of the stomach, affect blood coagulation as much as NSAIDs, or affect function of the kidneys
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