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Case reports document melanoma in users and rapid changes in pigmented lesions, with a 2025 report specifically questioning whether Melanotan II nasal spray is a risk factor for oral mucosal malignant melanoma
Eberly LA, Yang L, Essien UR, Eneanya ND, Julien HM, Luo J, et al
Mounjaro is currently available by prescription for type 2 diabetes
Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks