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Because Isotretinoin affects the liver and skin, combining it with certain drugs, supplements, or substances can increase the risk of side effects like liver damage, dryness, or even more severe complications

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Cao XF, Dai YJ, Liu MY, Yuan XY, Wang CC, Huang YY, Liu MY, Jiang GZ (2019) High-fat diet induces aberrant hepatic lipid secretion in blunt snout bream by activating endoplasmic reticulum stress-associated IRE1/XBP1 pathway

Injecting the wrong site for the goal