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Metabolic research moved from single GLP-1 agonism to dual GLP-1 plus GIP, to triple action across GLP-1, GIP, and glucagon

On July 7, 2026, Trutakna (atacicept) became the first and only approved therapy that blocks both BAFF and APRIL the two cytokines that sit furthest upstream in IgA nephropathy, driving B cells to produce the abnormal antibody that deposits in and damages the kidneys

Researchers became interested in the fragment because it appeared to retain some of the signaling activity of the parent molecule while being far smaller and easier to work with

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