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The 72-hour threshold is not an official manufacturer guideline it's a practical working limit based on how quickly bacterial growth can become concerning at typical room temperatures (2025C) even in the presence of benzyl alcohol

The review found benefits most pronounced over supplementation periods of six months or longer, reinforcing the importance of consistent daily use rather than short-term supplementation for meaningful body composition changes from CLA specifically

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Fix: Track calories, ensure consistent deficit, prioritize protein

PMCID: PMC8813037.