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Cardiovascular disease and IR Cardiovascular diseases (CVDs) are the leading causes of death globally

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In diet-induced obese mice, 30 days of once-daily subcutaneous dosing limited fat-mass gain to 1.3 g versus 4.7 g in controls, but only at 32 mg/kg/day

It does this by binding to a specific receptor on the surface of pigment cells (melanocytes) called the melanocortin 1 receptor (MC1R)

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