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176 Similar to G-protein-coupled receptors (GPCRs), 2-AR has seven transmembrane-spanning -helices (i.e., hepta-helical domains)

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32-34 Acute toxicities arise from sudden exposures to substantial quantities of some metals (such as from occupational exposure to aluminum dust or breaking a mercury-containing thermometer) and typically affect multiple organ systems, commonly the gastrointestinal tract, cardiovascular system, nervous system, endocrine system, kidneys, hair, and nails