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Multiple meta-analyses further revealed this complexity: A meta-analysis on the body component modification effect of GLP-1 receptor agonists showed that compared with the control group, GLP-1RA users not only had a significant reduction in fat body mass, but also a more obvious reduction in lean body mass (weighted mean difference was 1.02 kg) [55]

There were 632 participants with T2DM and insufficient glycemic controldefined as an A1C between 7.0% and 9.5%despite lifestyle interventions alone or treatment with a stable dose of metformin

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Why Trust Everyday Health Caitlin Beale, MS, RDN Author Caitlin Beale, MS, RDN, is a registered dietitian and freelance health writer with experience in clinical nutrition, education, research, and private practice

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