The neuroprotective role of estrogens implies a close regulation of processes such as (i) anti-oxidant activity (Kumar et al., 2010), (ii) DNA repair (Scharfman and MacLusky, 2006), (iv) synaptic plasticity (McEwen and Milner, 2007), and (v) the blood flow to the brain (Zhao and Brinton, 2006
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exceeds $50 billion [1, 2]
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Such interactions are particularly critical for narrow-therapeutic-index drugs like warfarin, digoxin, and flecainide, where minor dosage changes can trigger severe adverse effects (86)