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Because of these concerns, it is essential for clinicians to screen for eating disorders before prescribing GLP-1RAs in individuals with overweight or obesity

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The semaglutide component has proven cardiovascular benefit from SELECT trial

This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)