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While postbiotics are unlikely to replicate the magnitude of weight loss achieved with GLP-1RAs, their continuous, physiology-aligned mode of action positions them as biologically plausible adjuncts that may support weight-loss sustainability and improve the metabolic context for lean mass preservation

It involves administering a moderate dose daily for a short period before tapering down to a less frequent maintenance schedule

Generative AI statement The author(s) declared that generative AI was used in the creation of this manuscript

As patients lose weight, they typically find more energy and increased mobility, making it easier to engage in an active lifestyle

The question of whether compounded semaglutide really expires after 28 days is one of the most common concerns for those using telehealth platforms