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The Bottom Line Retatrutide leads on trial data, with about 24.2% mean weight loss at 48 weeks against roughly 20.9% for tirzepatide
Adherence to the schedule matters, as missed doses can stall progress
Prioritize adequate sleep (79 hours) and stress management for adherence and recovery
Three overlapping mechanisms make NSAIDs a poor routine choice on GLP-1 therapy: additive upper-GI irritation, unpredictable absorption caused by slowed gastric emptying, and compounded renal stress
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