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It is a growth hormone-releasing factor analogue

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In pooled analyses of the STEP-HFpEF (Semaglutide Treatment Effect in People with obesity and HFpEF) and STEP-HFpEF-DM trials, GLP-1 RA had consistent beneficial effects on HF-related symptoms, exercise function, and inflammatory markers in patients receiving diuretics with obesity-related HFpEF [82]

It is important to recognize that the establishment of reference intervals is influenced by several factors, including population characteristics, geographical variations, and testing methodologies [21, 22]