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Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature
In Hamburg, researchers in the lab of Kay Grnewald, head of the Department of Structural Cell Biology at LIV, UHH and CSSB, produced a gB protein preparation that colleagues in Gttingen then used to immunize an alpaca, triggering the production of antibodies
Furthermore, there was no differential impact of treatment (versus placebo) on metabolic parameters in MC4R mutation carriers versus noncarriers (Extended Data Table 3)
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