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Metabolites were normalized to total ion count of each sample

A: Intravenous glutathione administration delivers glutathione directly into systemic circulation, bypassing hepatic first-pass metabolism

Along with the breakdown of antioxidant defenses, there can be dramatic skin membrane lipid peroxidation, triggering ferroptosis, a skin cell death

Direct contact between the peptide and esophageal tissue during swallowing provides local exposure in addition to systemic effects achieved after absorption

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