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Dietary quality and consistency represent the most controllable variable influencing tirzepatide outcomesusers who maintain a calorie deficit and prioritize protein intake typically see faster, more substantial weight loss than those relying solely on appetite suppression

By requiring prior authorization, insurers aim to: Ensure the appropriate use of expensive medications

Drug interactions

For the 670 randomized patients, at study entry (Week 0) mean body weight was 107.3 kg and mean BMI was 38.4 kg/m2, and at randomization (Week 36, after the open-label ZEPBOUND lead-in period) mean body weight was 85.2 kg and mean BMI was 30.5 kg/m2

Most patients tolerating both well benefit from continuing 500 mg daily carnitine through their entire tirzepatide course