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Antiviral therapies, such as nucleos(t)ide analogs and interferons, can control viral replication but rarely cure the infection due to the persistence of HBV covalently closed circular DNA (cccDNA) ( While HBV alone can drive CHB, cirrhosis, and HCC, concurrent alcohol use accelerates liver damage, increases HBV persistence, and raises the risk of malignancy

Cranial cruciate ligament (CCL) disease the canine equivalent of a human ACL tear is among the most common orthopedic conditions, especially in medium and large breeds