Greenberger, University of Pittsburgh Medical Center-Shadyside, USA Copyright 2014 Aquilano, Baldelli and Ciriolo
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However, the participation of GPER-1 in these cellular responses was not specifically verified
Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly
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