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The larger protein from which TB-500 is derived, thymosin beta-4, has been associated with cancer in lab studies, but the agency reviewers said that no such research has been done on TB-500

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GSH deficiency results in the activation of von Willebrand Factor (Ibrahim et al., 2004) and in the accumulation of ROS, which affect clotting and platelet activation, impair endothelial function, and predispose to the risk of thrombotic events (Violi et al., 2017): notably, hypercoagulation is a prominent life-threatening complication in COVID-19 patients (Giardini et al., 2020)

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