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The improvement of this functional marker may indicate an important pathway towards new therapeutic strategies that target glutathione dysregulation in schizophrenia

At 24 weeks (the last point before people taking a placebo were eligible to switch to orforglipron), people taking a placebo had roughly gained 20 pounds back on average, no matter which drug they were taking originally

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NICE guidance on obesity management emphasises that pharmacological interventions like Wegovy should be combined with a reduced-calorie diet and increased physical activity for maximum benefit