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If you notice diminishing benefits, reduce to three times weekly or add rest days
[7] [8] This triple-receptor mechanism distinguishes it from existing approved agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GLP-1/GIP agonist)
These differences matter clinically: larger average weight loss translates into bigger improvements in blood pressure, glycemic measures, sleep apnea metrics, mobility, and quality of life for many patients
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