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Taking medications that hamper your bodys ability to absorb vitamin B12, including metformin and proton pump inhibitors (PPIs), drugs that treat heartburn and acid reflux
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The mechanisms involved, gene expression modulation, collagen synthesis, tissue remodeling, operate on timescales of weeks to months
Vegetarians and vegans often face challenges in obtaining sufficient B12 from their diet, so supplementation becomes necessary
The exact amount depends on the patients health, how bad the deficiency is, and the doctors advice
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