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"Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways"

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Forrest JA, Clements JA, Prescott LF

The 100mg cohort showed statistically significant reductions in visceral adipose tissue (8.3% vs baseline) and improvements in insulin sensitivity (HOMA-IR reduction of 18.7%), but no hepatotoxicity signals emerged across any dose tier