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This transition may involve: Temporary increases in oxidative signaling Activation of immune and repair pathways Increased demand for nutrients that support redox balance Why You May Feel Worse Before You Feel Better After Quitting As detoxification and repair processes accelerate, symptoms can temporarily intensify

When it binds with copper, it becomes biologically active in ways that are highly relevant to skin repair and regeneration

ONeil PM, et al

The implication for clinical practice is that restoring youthful MOTS-c signaling might be a mechanistically legitimate target for longevity intervention

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