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doi: 10.1111/HEAD.14197 57 TrigoJGarca-AzornDPlanchuelo-GmezAMartnez-PasETalaveraBHernndez-PrezIet al

It is a treatment for deficiency, not a general energy supplement

Increased notch activity in T2D induces expression of SREBP1 in liver through constitutive activation of mTORC1, promoting fat deposition, and increases expression of G6Pase and PEPCK in liver in a FOXO1-dependent manner, promoting glucogenesis, and ultimately exacerbating IR

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TIER PLANS TIER 0 (20mg total) $279 total for 10 week supply Monthly cost breakdown: $111 Recommended if using low (or micro) doses of 2mg/week or less TIER 1 (40mg total) $319 total for 8-10 week supply Monthly cost breakdown: $127-$160 based on weekly dose Recommended if new to treatment or for those on 2-5mg/week TIER 2 (60mg total) $339 total for 8-10 week supply Monthly cost breakdown: $135-$169 based on weekly dose Recommended for those on 6-7mg/week TIER 3 (80mg total) $429 total for 8-10 week supply Monthly cost breakdown: $171-$214 based on weekly dose Recommended for those on 8-10mg/week TIER 4 (120mg total) $579 total for 8-10 week supply Monthly cost breakdown: $231-$289 based on weekly dose Recommended for those on 11mg/week and up MONTHLY PLANS Monthly Starter Dose $175 total for one month supply Recommended if new to treatment or for those on doses of 2.5mg/week or less Monthly Mid Dose $235 total for one month supply Recommended for doses up to 7.5mg/week Monthly Advanced Dose $250 total for one month supply Recommended for doses of 7.5-10mg/week Monthly Advanced Plus Dose $295 total for one month supply Recommended for doses of 11mg/week and up OptioRX Pharmacy - Tirzepatide/Niacinamide Injection Up to 90 days BUD