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Oral & compounded formulations of GLP-1 are not reviewed by the FDA for safety, efficacy, or quality

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Other studies using rodents or primates with immunofluorescent reporter GLP-1Rs verify the expression of GLP-1Rs by pyramidal (glutamergic), GABAergic and catecholaminergic neurons in feeding, energy homeostasis, fear, stress, motivation/reward, learning plus memory as well as Alzheimers disease (AD) and Parkinsons Disease (PD)-associated key brain areas, such as the hippocampus, hypothalamus, cortex, striatum, amygdala, SNpc, or ventral tegmental area (VTA) (Cork et al., 2015

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Drug interactions There is an increased risk of hypotension when SGLT2 inhibitors are used with drugs that may cause hypotension