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Key findings Related Stories Genetic variants interact to increase early-onset atrial fibrillation risk When sleep changes in women over 80, it may signal more than aging Small changes in one heart protein cause distinct cardiomyopathies Within six months of starting GLP-1 therapy, the rate of hypotensive events increased from 8.7% to 10.2% The increased risk remained significant at 12 months, with hypotensive events rising from 13.6% to 14.3% Adults age 65 and older accounted for 53% of hypotensive events despite representing 37% of the study population Patients with Type 2 diabetes made up 75% of those experiencing hypotensive episodes but only 63% of the overall cohort In secondary analyses, the scientists found that weight loss alone did not explain the increased risk, suggesting other mechanisms of action may be at play Below is a Q&A with study senior author Dr

The enrichment of platelet homeostasis pathways suggests a potential link between metabolic dysregulation and platelet function in the context of HF, highlighting the importance of understanding platelet biology in CV pathophysiology

The cumulative incidence was 6.7% for semaglutide versus 0.8% for the non-GLP-1 RA group over 36 months

BPC-157 should be kept in a cool, dry place and protected from light and moisture

These cells remain metabolically active, adopt a distinct phenotype (including chromatin changes), and critically secrete a variety of pro-inflammatory cytokines, proteases, growth-factors and extracellular-matrix modifying signals