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In the ensuing wave of similar drugs, Zepbound (tirzepatide) has shown a lot of promise for chronic weight management and has also been approved to treat obstructive sleep apnea (OSA) in people with obesity
This helps avoid any issues that could impact stability
It's part of why many providers aren't raising it yet, and why it's worth you raising it with them
Expression vectors (pFUSE2ss) encoding GLP-1 fused to the N-terminal end of albumin were constructed by sub-cloning cDNA fragments encoding two tandem GLP-1 peptide sequences (residues 736), both with the A2G substitution, in-frame of cDNA encoding human albumin variants (WT, LX, QMP, or QMP/LX) using the restriction enzyme sites EcoRI and Nhel (GenScript)
These include: Gallstones: Associated with GLP-1s, the risk of gallstones is less than 2%
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