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Ultimately, the obesity market will likely develop in a complex and unpredictable way, which will likely include both subcutaneous and oral products and combinations, with patients seeking cleaner side-effect profiles and becoming more averse to the ever-more publicized risks

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Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: A 54-Week randomized phase 2b study

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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default