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Lv L, et al

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Step 2: Assess risk features Determine whether the patient is in dose escalation, has active GI symptoms, uses a high dose, has known gastroparesis, has long-standing diabetes with autonomic neuropathy, has severe GERD or hiatal hernia, or is undergoing general anesthesia/deep sedation

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But the additional GIP receptor binding domain makes tirzepatide a fundamentally different pharmacological tool

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GLP-1-agonist induced cell proliferation of activated PSCs without increasing release of inflammatory mediators

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Richele Corrado, an obesity medicine physician and spokesperson for The Obesity Society

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