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Although mechanisms of bisphenol A action are probably diverse, it should be underlined with respect to the topic of the present review that this EDC increases the generation of hydrogen peroxide (H 2 O 2 ), being one of the basal forms of ROS, in vitro and in vivo models (via increasing DUOX2 [the enzyme responsible for H 2 O 2 generation in the thyroid] mRNA level) and decreases iodine uptake (reduces NIS mRNA level) and TPO activity [45]
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