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To improve the prognosis of metastatic TNBC patients, antibodydrug conjugates (ADCs), such as sacituzumab govitecan, have been utilized to specifically deliver potent chemotherapy agents directly to cancer cells expressing targeted antigens, demonstrating promising efficacy [25]

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Intriguingly, MRI evidence of BBB disruption has been noted in seemingly normal white matter even before the emergence of enhancing lesions, as well as in non-enhancing regions, implying that BBB impairment precedes both clinical symptoms and other MRI-evident changes in the disease course

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