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The hypoglycemic agents that have been studied to achieve the most favorable results are glucagon-like-1 receptor agonists (GLP-1RAs) and peroxisome proliferator-activated receptor-gamma agonists (PPAR), which are currently undergoing phase 2 studies
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Despite increased GLP-1 levels and incretin receptor expression on beta cells, the lower glucose levels achieved with metformin treatment were not associated with increased insulin levels [10]
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